Optimizing microarray in experimental hypertension
نویسندگان
چکیده
منابع مشابه
Microarray analysis in pulmonary hypertension
Microarrays are a powerful and effective tool that allows the detection of genome-wide gene expression differences between controls and disease conditions. They have been broadly applied to investigate the pathobiology of diverse forms of pulmonary hypertension, namely group 1, including patients with idiopathic pulmonary arterial hypertension, and group 3, including pulmonary hypertension asso...
متن کاملExperimental Hypertension
Unilateral renal ischemia superimposed upon intestinal ischemia has resulted in a prolonged elevation in the arterial blood pressure in a high percentage of the animals which were studied.
متن کاملExperimental Validation of Microarray Data
In this chapter, we describe a few popular experimental methodologies that can be used to independently validate the results of a microarray experiment. In contrast to many of the other chapters in this book, the techniques described here are decidedly non-mathematical or statistical in nature. Instead, most of them utilize standard 'wet-bench' molecular biology protocols that have proven thems...
متن کاملHemostasis imbalance in experimental hypertension.
BACKGROUND The rat model of chronic intoxication by N(G) -nitro-L-arginine methyl ester (L-NAME) induces severe systemic arterial hypertension and progressive ischemic lesions in the central nervous system and kidneys. We investigated the possible molecular basis of these thrombotic events. METHODS AND RESULTS Administration of L-NAME increased plasma markers of thrombin generation, thrombin-...
متن کاملIon shift in experimental hypertension.
Rabbits weighing from 2000 to 2500g were divided into the following groups: Group Ncontrol animals. Group D-animals with blood pressure elevated in metacorticoid hypertension elicited by the administration of desoxycorticosterone acetate and sodium chloride. Group Eanimals with blood pressure elevated by repeated doses of Ephedrinum basicum solutio oleosa (100mg/kg) every 2nd day during 2 weeks...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2005
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2005.00090.x